HORDB

ID: hor005617
Uniprot ID: V9QER4
Protein name: Alpha-latrotoxin associated low molecular weight protein SGV242-280
Gene name: NA
Organism: Steatoda grossa (False black widow)
Family: arthropod CHH/MIH/GIH/VIH hormone family
Source: animal
Expression: Expressed by the venom gland.
Disease: NA
Comments: NA
Taxonomy: Steatoda (genus), Theridiidae (family), Araneoidea (superfamily), Orbiculariae, Entelegynae, Araneomorphae (suborder), Araneae (order), Arachnida (class), Chelicerata (subphylum), Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: GO:0005576 extracellular region

Sequence: IEPQDIGCTGISTAEFEEKDATCSKCEEDYSGNGMIDRCRSDCYSGPFFKSCVELLNKGYDEKDENVKPEW
Length: 71
Propeptide: MSKLHFLILLSVIVSVFCIEPQDIGCTGISTAEFEEKDATCSKCEEDYSGNGMIDRCRSDCYSGPFFKSCVELLNKGYDEKDENVKPEW
Signal peptide: MSKLHFLILLSVIVSVFC
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: May increase the toxicity of alpha-latrotoxin and/or other venom components. Is non-toxic to mice and to the cockroach Periplaneta americana
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor005617_AF2.pdb

hor005617_ESM.pdb

Mass:	926153	Formula:	C340H516N88O122S7
Absent amino acids:	H	Common amino acids:	E
pI:	4	Basic residues:	8
Polar residues:	27	Hydrophobic residues:	14
Hydrophobicity:	-87.18	Boman Index:	-17811
Half-Life:	20 hour	Half-Life Yeast:	30 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	43.94
Instability Index:	4736.34	Extinction Coefficient cystines:	10345
Absorbance 280nm:	147.79

PubMed ID: 24316130
Title: Recruitment and diversification of an ecdysozoan family of neuropeptide hormones for black widow spider venom expression.